The Biologic and Prognostic Role of Replicative and Oncogene Induced Senescence in Pediatric Low Grade Gliomas

Principal Investigator Dr. Uri Tabori,  Hospital for Sick Children, University of Toronto. 

This study will study why some PLGA tumors stop growing.  Using this alternative research strategy, we will build on previous results that demonstrated that a mechanism that controls tumor growth arrest, defined as senescence, predicts outcome in PLGA.  With the collaboration between three of the leading pediatric neuro-oncology centers in North America, we plan to expand our preliminary findings and to determine the pathways that control senescence in PLGA.  Upon completion of this project, we will be able to better predict which patients are unlikely to have tumor progression (and can thus be spared from current toxic therapies).  We will uncover novel targets as therapeutic options for PLGA.  Furthermore our findings will provide a framework for a new understanding of astrocytoma behavior in children.

PLGA Foundation recognizes the Brain Tumor Society (BTS) for their support on this project.